期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 42, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202000447
关键词
fluorescence; force sensors; mechanochromism; rotaxane
资金
- Wellcome Trust [208992/Z/17/Z]
- Wellcome Trust [208992/Z/17/Z] Funding Source: Wellcome Trust
A new mechanoresponsive fluorescent hydrogen-bonded rotaxane, built around a maleimide dye, is reported in this study. Its force-sensing properties are demonstrated in a polyacrylamide gel, a synthetic model of living tissue.
Tensile forces influence a variety of important biological processes and force sensors are required to study these processes in vivo. Current force sensors are often tailor-made for a specific application, or activate at much higher forces than those observed at the cellular or tissue level. A versatile force sensor, with tunable mechanical and optical properties, activated at low pN forces will be ideal. In this communication, a new mechanoresponsive fluorescent hydrogen-bonded rotaxane, built around a maleimide dye, is reported. Its force-sensing properties are demonstrated in a polyacrylamide gel, a synthetic model of living tissue.
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