期刊
LUMINESCENCE
卷 35, 期 8, 页码 1156-1173出版社
WILEY
DOI: 10.1002/bio.3831
关键词
fluorescence probe; hydrogen sulfide; nucleophilic reactions; red; near-infrared
资金
- Scientific Instrument Center of Shanxi University [201512]
- Natural Science Foundation of Shanxi Province of China [201901D111015]
- Key RAMP
- D Program of Shanxi Province [201903D421069]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019 L0031]
- Innovative Talents of Higher Education Institutions of Shanxi [2019]
- Shanxi Province Foundation for Selected [2019]
- Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes [2015-10-B3]
- Shanxi Province Foundation for Returness [2017-026]
- Xiangyuan County Solid Waste Comprehensive Utilization Science and Technology Project [2018XYSDJS-05]
- National Natural Science Foundation of China [21907062, 21775096]
The topics of human health and disease are always the focus of much attention. Hydrogen sulfide (H2S), as a double-edged sword, plays an important role in biological systems. Studies have revealed that endogenous H2S is important to maintain normal physiological functions. Conversely, abnormal levels of H2S may contribute to various diseases. Due to the importance of H2S in physiology and pathology, research into the effects of H2S has been active in recent years. Fluorescent probes with red/near-infrared (NIR) emissions (620-900 nm) are more suitable for imaging applicationsin vivo, because of their negligible photodamage, deep tissue penetration, and maximum lack of interference from background autofluorescence. H2S, an 'evil and positive' molecule, is not only toxic, but also produces significant effects; a 'greedy' molecule, is not only a strong nucleophile under physiological conditions, but also undergoes a continuous double nucleophilic reaction. Therefore, in this tutorial review, we will highlight recent advances made since 2015 in the development and application of red/NIR fluorescent probes based on nucleophilic reactions of H2S.
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