Combined analysis ofIKZF1deletions andCRLF2expression on prognostic impact in pediatric B-cell precursor acute lymphoblastic leukemia

This study aimed to investigate the combined impact ofIKZF1deletions/high expression ofCRLF2on the prognosis of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).IKZF1deletions andCRLF2expression were assessed in bone marrow samples from 117 children with newly diagnosed BCP-ALL. Sixteen (13.7%) patients were found to harborIKZF1deletions, which was associated with inferior outcomes. The event-free survival (EFS) for patients with high -CRLF2expression was significantly worse than that for low -CRLF2expression. Moreover, combined modeling ofIKZF1(+)/CRLF2(high)identified 7.8% of cases as the highest risk subgroup (7-year EFS 33.3 +/- 15.7%). In a multivariate analysis,IKZF1(+)/CRLF2(high)remained a strong independent prognostic factor for EFS (HR: 14.263,p = 0.019).IKZF1deletions and high -CRLF2expression were associated with inferior outcomes, and the coexistence ofIKZF1(+)/CRLF2(high)had a significant impact on an integrated prognostic model for high-risk BCP-ALL.

Automated summary

This study found that in pediatric BCP-ALL, IKZF1 deletions and high CRLF2 expression lead to inferior outcomes. Additionally, the coexistence of IKZF1(+)/CRLF2(high) has a significant impact on the prognosis of high-risk BCP-ALL patients.