期刊
LEUKEMIA & LYMPHOMA
卷 62, 期 1, 页码 76-85出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2020.1817438
关键词
Diffuse large B-cell lymphoma; regulatory T-cells (Tregs); CD25; FOXP3; prognosis
资金
- Ministry of Science and Technology, Taiwan [MOST 106-2320-B-006-037-MY3, 109-2320-B-006-045-MY3]
In patients with DLBCL, a higher number of intratumoral CD25 + FOXP3+ lymphocytes is associated with favorable prognosis, along with other clinical and pathological characteristics. This higher number of regulatory T-cells also correlates with increased infiltration by cytotoxic T-lymphocytes and nodal location.
Regulatory T-cells (Tregs) play an important role in cancer immunity but their prognostic impact is controversial in diffuse large B-cell lymphoma (DLBCL). Intratumoral Tregs in DLBCL (n = 70) were evaluated by double-stained CD25 and FOXP3 lymphocytes in formalin-fixed paraffin-embedded tissues, and correlated with clinicopathologic features. We found that increased numbers of intratumoral FOXP3+ lymphocytes (>2.4/HPF) and CD25 + FOXP3+ lymphocytes (>0.8/HPF) are favorable prognosticators (p = .004 andp < .001, respectively) in DLBCL patients, along with age <70 years, stage I-II disease, normal serum LDH level and low IPI scores (p < .001, .002, .002, and <.001, respectively). On multivariate analyses, a higher number of CD25 + FOXP3+ lymphocytes retained prognostic significance (p = .040). Interestingly, higher Treg infiltration correlated with increased infiltration by cytotoxic T-lymphocytes (gamma = 0.294,p = .038) and nodal location (gamma = 0.390,p = .004), but not with infiltration by CD123+ plasmacytoid dendritic cells, which were reported to induce Tregs with immune tolerance. Therefore, congruent with literature meta-analyses, higher intratumoral CD25 + FOXP3+ lymphocytes have a beneficial impact on DLBCL.
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