期刊
LETTERS IN DRUG DESIGN & DISCOVERY
卷 18, 期 3, 页码 249-257出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570180817999201001155032
关键词
Chalcones; bis-chalcones; reactive oxygen species (ROS); DPPH; ABTS; in vitro
资金
- Pakistan Academy of Sciences [5-9/PAS/440]
- NAM ST
The study evaluated the antioxidant potential of synthetic chalcones and bis-chalcones, revealing their significant scavenging activity against DPPH and ABTS radicals. The structure-activity relationship showed the active participation of various groups, such as -SMe and -OMe, in the scavenging activity.
Background: A number of synthetic scaffolds, along with natural products, have been identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted. medicinally distinct class of compounds chalcones and bis-chalcones for their antioxidant potential. Methods: In vitro radical scavenging activities were performed on a series of synthetic chalcones 1-13 and bis-chalcones 14-18. Results: All molecules 1-18 revealed a pronounced 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging potential in the ranges of IC50s = 0.58 +/- 0.14 - 1.72 +/- 0.03 and 0.49 +/- 0.3 - 1.48 +/- 0.06 mu M, respectively. Ascorbic acid (IC50s = 0.5 +/- 0.1 and 0.46 +/- 0.17 mu M for DPPH and ABTS, respectively) was used as a standard radical scavenger. Conclusion: Structure-activity relationship (SAR) revealed an active participation of various groups, including -SMe and -OMe in scavenging activity.
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