期刊
LETTERS IN APPLIED MICROBIOLOGY
卷 72, 期 3, 页码 220-224出版社
OXFORD UNIV PRESS
DOI: 10.1111/lam.13419
关键词
antimicrobial resistance; dairy cows; fluoroquinolones; macrolides; third‐ generation cephalosporins
资金
- USDA-NIFA-AFRI [2016-68003-24607]
This study found that the transfer of antimicrobial resistance genes can result in the selection of resistance, even without the use of antimicrobials. A previously unreported combination of resistance genes in Escherichia coli was identified, including genes for antibiotics only used in dairy cattle under 20 months of age. The antibiotics resistant to these genes are considered critically important and highest priority for human medicine by the World Health Organization.
The transfer of antimicrobial resistance genes commonly occurs via vertical and horizontal gene transfer, as such genes are often found on the same mobile genetic element. This occurrence can lead to the co-selection of resistance to antimicrobials without their application. Dairy cattle located in the south-western United States were enrolled in a matched-pair longitudinal study to evaluate the effects of a two-dose ceftiofur treatment for metritis on levels of third-generation cephalosporin resistance among faecal Escherichia coli temporally. Escherichia coli chosen for further investigation were isolated on selective media, harboured extended-spectrum beta-lactam, fluoroquinolone and macrolide resistance genes. This combination has previously been unreported; importantly, it included genes encoding for resistance to antibiotics that can only be used in dairy cattle less than 20 months of age. Fluoroquinolones, macrolides and third and higher generation cephalosporins are considered critically important and highest priority for human medicine by the World Health Organization.
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