期刊
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
卷 76, 期 6, 页码 1195-1205出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/geronb/gbaa144
关键词
Immune aging; Life course studies; Persistent infections; Socioeconomic disadvantage
资金
- National Institute on Aging [AG000029-41, K99AG062749]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [T32 HD091058]
This study investigated the association between life course socioeconomic disadvantage and immune response to cytomegalovirus (CMV) among older adults. Findings showed a significant association between educational attainment and parental education with CMV IgG response. This suggests that both early-life and adult SES may contribute to disparities in immunological aging.
Objectives: Previous research has documented a consistent association between current socioeconomic status (SES) and cytomegalovirus (CMV). Early life is likely a critical period for CMV exposure and immune development, but less is known about early-life socioeconomic factors and CMV, particularly in older age populations. Using data from the Health and Retirement Study, we investigated the association between life course socioeconomic disadvantage and immune response to CMV among older adults. Methods: Using ordered logit models, we estimated associations between several measures of socioeconomic disadvantage and the odds of being in a higher CMV Immunoglobulin G (IgG) response category in a sample of 8,168 respondents aged older than 50 years. Results: We found a significant association between educational attainment and CMV IgG response. Those with less than a high school education had 2.00 (95% confidence interval [CI]: 1.67-2.40) times the odds of being in a higher CMV category compared to those with a college degree or greater. In addition, we also observed a significant association with parental education and CMV response. Individuals with parents having 8 years or less of schooling had 2.32 (95% CI: 2.00-2.70) times the odds of higher CMV response compared to those whose parents had greater than high school education. Discussion: CMV IgG levels in older adults are associated with both early-life and adult SES. Life course socioeconomic disadvantage may contribute to disparities in immunological aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据