期刊
JOURNAL OF TRAVEL MEDICINE
卷 27, 期 8, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jtm/taaa200
关键词
COVID-19; SARS-CoV-2; intercontinental transmission dynamics; air travel; population mobility; SEIR model; Bayesian phylodynamics
资金
- Key Research and Development Project of Shandong Province [2020SFXGFY01, 2020SFXGFY08]
- National Key Research and Development Programme of China [2020YFC0840800, 2016YFE0205800]
- Strategic Priority Research Programme of the Chinese Academy of Sciences [XDB29010102, XDA19090118]
- National Natural Science Foundation of China [32041010, 81773498]
- National Science and Technology Major Project of China [2016ZX10004222-009]
- Academic Promotion Programme of Shandong First Medical University [2019QL006, 2019RC010]
- Bill & Melinda Gates Foundation [OPP1170969, OPP1106427, OPP1032350, OPP1134076, OPP1094793]
- European Union [MOOD 874850]
- National Major Project for Control and Prevention of Infectious Disease in China [2017ZX10104001, 2018ZX10101004]
- National Natural Science Foundation of China Outstanding Young Scholars [31822055]
- Youth Innovation Promotion Association of CAS [2017122]
- Clinton Health Access Initiative, UK Department for International Development
- Wellcome Trust [106866/Z/15/Z, 204613/Z/16/Z]
- Young Taishan Scholars Program of Shandong Province of China [tsqn20161046]
- Taishan Scholars Programme of Shandong Province [ts201511056]
- China Postdoctoral Science Foundation [2020T130123ZX]
- Bill and Melinda Gates Foundation [OPP1170969] Funding Source: Bill and Melinda Gates Foundation
Background: The COVID-19 pandemic has posed an ongoing global crisis, but how the virus spread across the world remains poorly understood. This is of vital importance for informing current and future pandemic response strategies. Methods: We performed two independent analyses, travel network-based epidemiological modelling and Bayesian phylogeographic inference, to investigate the intercontinental spread of COVID-19. Results: Both approaches revealed two distinct phases of COVID-19 spread by the end of March 2020. In the first phase, COVID-19 largely circulated in China during mid-to-late January 2020 and was interrupted by containment measures in China. In the second and predominant phase extending from late February to mid-March, unrestricted movements between countries outside of China facilitated intercontinental spread, with Europe as a major source. Phylogenetic analyses also revealed that the dominant strains circulating in the USA were introduced from Europe. However, stringent restrictions on international travel across the world since late March have substantially reduced intercontinental transmission. Conclusions: Our analyses highlight that heterogeneities in international travel have shaped the spatiotemporal characteristics of the pandemic. Unrestricted travel caused a large number of COVID-19 exportations from Europe to other continents between late February and mid-March, which facilitated the COVID-19 pandemic. Targeted restrictions on international travel from countries with widespread community transmission, together with improved capacity in testing, genetic sequencing and contact tracing, can inform timely strategies for mitigating and containing ongoing and future waves of COVID-19 pandemic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据