期刊
JOURNAL OF TRANSLATIONAL MEDICINE
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12967-020-02504-8
关键词
Paracrine; Autocrine; Endocrine; Mesenchymal stem cells; Remote delivery
资金
- Montreal Heart Institute Foundation
- TheCell Network (Fond de Recherche du Quebec-Sante FRQS)
- Chaire DesGroseillers-Berard en Cardiologie Interventionnelle
- Chaire Fondation Marcelle et Jean Coutu de traitements chirurgicaux novateurs en insuffisance cardiaque from Universite de Montreal
In the past decade, despite key advances in therapeutic strategies following myocardial infarction, none can directly address the loss of cardiomyocytes following ischemic injury. Cardiac cell-based therapy is at the cornerstone of regenerative medicine that has shown potential for tissue repair. Mesenchymal stem cells (MSC) represent a strong candidate to heal the infarcted myocardium. While differentiation potential has been described as a possible avenue for MSC-based repair, their secreted mediators are responsible for the majority of the ascribed prohealing effects. MSC can either promote their own survival and proliferation through autocrine effect or secrete trophic factors that will act on adjacent cells through a paracrine effect. Prior studies have also documented beneficial effects even when MSCs were remotely delivered, much akin to an endocrine mechanism. This review aims to distinguish the paracrine activity of MSCs from an endocrine-like effect, where remotely transplanted cells can promote healing of the injured myocardium.
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