Synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the magnetized deionized water based on UV-visible study

A green synthetic route to the facile one-pot multicomponent synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines have been developed using magnetized deionized water (MDW) as a green solvent under catalyst-free conditions. All reactions carried out in a short period of time and the products are obtained in high-to-excellent yields. The developed synthetic technique offers numerous advantages including eco-friendly, clean synthesis, simplicity, low cost, short reaction times, high reaction yields, and easy workup compared to the traditional synthetic method. Moreover, the reaction rates were followed spectrophotometrically by monitoring the changes in the absorption spectrum of the reaction mixture in ordinary deionized water and MDW.

Automated summary

A green synthetic route using MDW as solvent has been developed for the facile one-pot multicomponent synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines. The reactions are fast and yield high product amounts.