期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 76, 期 13, 页码 1595-1604出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2020.07.056
关键词
cognitive impairment; computed tomography; dementia; epidemiology; histology; intracranial arterial calcification; stroke
资金
- European Research Council under the European Union [637024, 666881]
- European Research Council (ERC) [637024] Funding Source: European Research Council (ERC)
Intracranial large and small arterial calcifications are a common incidental finding on computed tomography imaging in the general population. Here we provide an overview of the published reports on prevalence of intracranial arterial calcifications on computed tomography imaging and histopathology in relation to risk factors and clinical outcomes. We performed a systematic search in Medline, with a search filter using synonyms for computed tomography scanning, (histo)pathotogy, different intracranial arterial beds, and calcification. We found that intracranial calcifications are a frequent finding in all arterial beds with the highest prevalence in the intracranial internal carotid artery. In general, prevalence increases with age. Longitudinal studies on calcification progression and intervention studies are warranted to investigate the possible causal rote of calcification on clinical outcomes. This might open up new therapeutic directions in stroke and dementia prevention and the maintenance of the healthy brain. (C) 2020 by the American College of Cardiology Foundation.
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