期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 37, 页码 15678-15685出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c08205
关键词
-
资金
- National Key R&D Program of China [2016YFA0202900]
- National Natural Science Foundation of China [21821002, 91856201, 21961132002]
- CAS [XDB20000000, QYZDY-SSW-SLH012]
- Science and Technology Commission of Shanghai Municipality [18JC1411302, 19590750400]
- Tencent Foundation through the XPLORER PRIZE
- Initiative Postdocs Supporting Program [BX20180342]
- China Postdoctoral Science Foundation [2019M650092]
- Pharmaron
Rhodium(III)-catalyzed enantioselective oxidative C-H/C-H cross-coupling reaction between two arenes is disclosed. With the combination of a chiral CpRh(III) complex and a chiral carboxylic acid additive, the direct coupling reactions between 1-aryl isoquinoline derivatives and electron-rich heteroarenes such as thiophenes, furans, benzothiophenes, and benzofurans are realized via a double C-H functionalization process. A series of axially chiral compounds are obtained in excellent yields and enantioselectivities (up to 99% yield and 99% ee). Mechanistic studies suggest that both C-H bond cleavages may not be the turnover-limiting step.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据