期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 36, 页码 15230-15234出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c02954
关键词
-
资金
- NSF [MCB-1409402, MCB-1947720]
Our understanding of biological chemistry is shaped by the observation that all life comes from other life-as Pasteur put it, omne vivum ex vivo. A key step in expanding our biochemical vocabulary is to recapitulate biogenic catalysis using non-natural sequences that did not arise from common ancestry. Here we describe an enzyme designed completely de novo that hydrolyzes ATP. This protein was designed to lack beta-sheet structure and is competitively inhibited by magnesium, two traits that are unlike natural ATPases.
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