期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 38, 页码 16211-16217出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c07810
关键词
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资金
- SERB-CRG grant [CRG/2018/000133]
- SERB-STAR AWARD grant [STR/2019/000045]
- SERB-SUPRA grant [SPR/2019/000158]
- CSIR
- SERB
A concept for intramolecular denitrogenative C(sp(3))-H amination of 1,2,3,4-tetrazoles bearing unactivated primary, secondary, and tertiary C-H bonds is discovered. This catalytic amination follows an unprecedented metalloradical activation mechanism. The utility of the method is showcased with the short synthesis of a bioactive molecule. Moreover, an initial effort has been embarked on for the enantioselective C(sp(3))-H amination through the catalyst design. Collectively, this study underlines the development of C(sp(3))-H bond functionalization chemistry that should find wide application in the context of drug discovery and natural product synthesis.
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