期刊
JOURNAL OF SEPARATION SCIENCE
卷 43, 期 22, 页码 4131-4147出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.202000498
关键词
active ingredients; mass; metabolites; prototype constituents; traditional Chinese medicine
资金
- Excellent and top talents programin Colleges and Universities
- NationalNatural Science FundRegional Innovation and Development Joint Fund Project
- Anhui ProvincialKey Laboratory of Traditional Chinese Medicine Compounds
- Anhui Provincial College Natural Science Research Key Project
- Open project of national key clinical specialty (traditional Chinesemedicine surgery)
- Natural ScienceResearch Project ofColleges and Universities in Anhui Province
- AnhuiUniversityCollaborative Innovation Project
Taohong Siwu Decoction is a classic Chinese medicine prescription for treatment of cerebral ischemia and gynecological diseases. However, the active ingredients of Taohong Siwu Decoction have not been identified. In this study, a ultra performance liquid chromatography quadrupole time-of-flight mass system was used to analyze the active components and metabolites of Taohong Siwu Decoction absorbed into the blood and the brain. A total of 39 active compounds and 90 metabolites were identified in the blood and brain by comparing retention times, accurate masses, fragmentation patterns, and literature data. The results showed that flavonoids (Carthamus tinctoriusL), aromatic organic acids, and benzoquinones (Angelica sinensis(Oliv.) Diels andLigusticumchuanxionghort) were prominent active ingredients in Taohong Siwu Decoction. Furthermore, hydrolysis, glucuronidation, and sulfation were identified as the main metabolic pathways of Taohong Siwu Decoction in vivo. This was the first study to characterize the active components and metabolites of Taohong Siwu Decoction in the blood and brain using ultra performance liquid chromatography quadrupole time-of-flight mass.
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