期刊
CORNEA
卷 35, 期 6, 页码 866-871出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICO.0000000000000825
关键词
nanostructured lipid carriers; voriconazole; ocular delivery
资金
- FAPEG (Fundacao de Amparo a Pesquisa do Estado de Goias) [201210267000265]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [483148/2011-3]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Purpose:To design and evaluate the potential of a topical delivery system for ocular administration of voriconazole, based on cationic nanostructured lipid carriers (NLCs).Methods:NLC dispersions composed of glyceryl behenate/capric caprylic triglyceride, polysorbate 80, sorbitan trioleate, and cetylpyridinium chloride were obtained and characterized. Ex vivo permeations experiments were performed to evaluate their drug delivery potential.Results:NLCs presented a mean diameter of 250.2 03.1 nm, narrow polydispersity index (0.288 +/- 0.03), positive zeta potential (31.22 +/- 3.8 mV), and over 75% encapsulation efficiency. Ex vivo ocular experiments proved that NLCs were able to deliver therapeutically relevant drug amounts to the cornea after only 30 minutes (13.88 +/- 0.24 g/cm(2)).Conclusions:The formulation was nonexpensive, easy to prepare, and composed of well-tolerated and accepted excipients. Further in vivo experiments are necessary to confirm the improved performance and tolerability of the formulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据