Preparation and characterization of memantine loaded polycaprolactone nanocapsules for Alzheimer's disease

Alzheimer is the most common cause of dementia in the elderly. Memantine is one of the approved drugs for treating this disease. In the present study, for the first time, a memantine release system based on polycaprolactone nanocapsules (MEM@PCL) was prepared and its physicochemical properties were investigated. The encapsulation efficiency of memantine was measured using high-performance liquid chromatography analysis as 80 +/- 3%. The physicochemical stability studies over 40 days revealed that the nanocapsules were stable in the solution without any aggregation.

Automated summary

In this study, a memantine release system based on polycaprolactone nanocapsules (MEM@PCL) was prepared for the first time, with an encapsulation efficiency of 80% as measured by high-performance liquid chromatography analysis. Physicochemical stability studies over 40 days demonstrated that the nanocapsules remained stable in solution without aggregation.