期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 11, 期 19, 页码 8077-8083出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.0c02412
关键词
-
类别
资金
- National Key R&D Program of China [2016YFA0501200, 2017YFA0505400]
- National Natural Science Foundation of China [21775161, 21927801, 31627803, 31770798, 21425523, 21921004]
- Chinese Academy of Sciences [YJKYYQ20190032]
- Estonian Research Agency
Proton-detected solid-state NMR has emerged as a powerful analytical technique in structural elucidation via H-1-H-1 correlations, which are mostly established by broadband methods. We propose a new class of frequency-selective homonuclear recoupling methods to selectively enhance H-1-H-1 correlations of interest under ultrafast magic-angle spinning (MAS). These methods, dubbed as selective phase-optimized recoupling (SPR), can provide a sensitivity enhancement by a factor of similar to 3 over the widely used radio-frequency-driven recoupling (RFDR) to observe H-1(N)-H-1(N) contacts in a protonated tripeptide N-formyl-Met-Leu-Phe (fMLF) under 150 kHz MAS and are successfully utilized to probe a long-range H-1-H-1 contact in a pharmaceutical molecule, the hydrochloride form of pioglitazone (PIO-HCl). SPR is not only highly efficient in frequency-selective recoupling but also easy to implement, imparting to it great potential to probe H-1-H-1 contacts for the structural elucidation of organic solids such as proteins and pharmaceuticals under ultrafast MAS conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据