期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 189, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jpba.2020.113473
关键词
Microbiota; Fungal infection; Aspergillus; Biomarkers; VOCs; Diagnosis
资金
- Fundacao para a Ciencia e a Tecnologia (FCT) [PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017]
- FCT [UIDB/50026/2020, UIDP/50026/2020, LCF/PR/HP17/52190003, SFRH/BD/136814/2018, CEECIND/03628/2017, CEECIND/04058/2018]
- Northern Portugal Regional Operational Programme (NORTE2020), under the Portugal 2020 Partnership Agreement, throughthe European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000013, NORTE-01-0145-FEDER-000023]
- European Union's Horizon 2020 research and innovation programme [847507]
- la Caixa Foundation [100010434]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/136814/2018] Funding Source: FCT
An emerging body of evidence has highlighted the significant role of the pulmonary microbiota during respiratory infections. The individual microbiome is nowadays recognized to supervise the outcome of the host-pathogen interaction by orchestrating mechanisms of immune regulation, inflammation, metabolism, and other physiological processes. A shift in the normal flora of the respiratory tract is associated with several lung inflammatory disorders including asthma, chronic obstructive pulmonary disease, or cystic fibrosis. These diseases are characterized by a lung microenvironment that becomes permissive to infections caused by the opportunistic fungal pathogen Aspergillus fumigatus. Although the role of the lung microbiota in the pathophysiology of respiratory fungal diseases remains elusive, microbiota-derived components have been proposed as important biomarkers to be considered in the diagnosis of these severe infections. Here, we review this emerging area of research and discuss the potential of microbiota-derived products in the diagnosis of respiratory fungal diseases. (C) 2020 Elsevier B.V. All rights reserved.
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