Bloodmyo-inositol concentrations in preterm and term infants

Objective To describe relationship between cord blood (representing fetal)myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age. Design/Methods Samples were collected in 281 fed or unfed infants born in 2005 and 2006.Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values. Results In 441 samples obtained from 281 infants,myo-inositol concentrations varied from nondetectable to 1494 mu mol/L. Cordmyo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatalmyo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants). Conclusions Fetalmyo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.

Automated summary

The study describes the relationship between cord blood myo-inositol concentrations and gestational age, as well as the trends of postnatal myo-inositol concentrations in fed and unfed infants up to 70 days of age. Findings indicate that fetal myo-inositol concentrations decrease with increasing gestational age, while postnatal concentrations decrease with increasing postmenstrual age and are higher in enterally fed infants compared to unfed infants.