期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 39, 期 2, 页码 258-264出版社
WILEY
DOI: 10.1002/jor.24896
关键词
biomaterials; infection
类别
Chronic osteomyelitis poses challenges in treatment due to bone infection and bacterial biofilm eradication. Novel biomaterials with unique properties are increasingly used to combat infection in this context, with ongoing debate about focusing on bone regeneration or antimicrobial properties.
Chronic osteomyelitis has always been a therapeutic challenge for patient and surgeon due to the specific problems related with bone infection and bacterial biofilm eradication. Other than being the cause of infection or facilitating spread or persistence of infection, biomaterials are also becoming a tool in the treatment of infection. Certain novel biomaterials have unique and ideal properties that render them perfectly suited to combat infection and are therefore used more and more in the treatment of chronic bone infections. In case of infection treatment, there is still debate whether these properties should be focused on bone regeneration and/or their antimicrobial properties. These properties will be of even greater importance with the challenge of emerging antimicrobial resistance. This review highlights indications for use and specific material properties of some commonly used contemporary biomaterials for this indication as well as clinical experience and a literature overview.
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