期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 16, 页码 10954-10961出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02049
关键词
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资金
- National Key Research and Development Program of China [2018YFC0310900]
- National Natural Science Foundation of China [U1605221, 81903524, 41729002, 41876145]
- Innovative research team of high-level local universities in Shanghai [SSMU-ZLCX20180702]
- Construction project of Shanghai Key Laboratory of Molecular Imaging [18DZ2260400]
- Shanghai Municipal Education Commission (Class II Plateau Disciplinary Construction Program of Medical Technology of SUMHS, 2018-2020)
- [GDNRC[2020]037]
Asperfloketals A and B, isolated from a sponge-associated fungus, exhibit strong anti-inflammatory activity without cytotoxicity against specific cell lines.
Asperfloketals A (1) and B (2), two 1(10 -> 6)-abeo-14,15-secosteroids featuring a novel trioxahexaheterocyclic ring system, were isolated from the sponge-associated fungus Aspergillus flocculosus 16D-1. Their structures were elucidated by extensive spectroscopic analysis and NMR chemical shifts calculations, supported by DP4+ probability analysis, and their absolute configurations were determined by ECD calculations and the modified Mosher's method. Asperfloketals A and B showed strong anti-inflammatory activity in the CuSO4-induced transgenic fluorescent zebrafish but displayed no cytotoxicity against HeLa, HepG2, and SW480 cell lines.
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