期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 18, 页码 11844-11855出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01603
关键词
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资金
- CSIR [MLP0154/MLP0159]
- UGC
- CSIR
The transition-metal-promoted C-H activation has become an efficient as well as atom-economic methodology for the synthesis of a wide array of organic molecules, but the cost of the metal catalyst and selectivity remain the major challenges. Herein, the first [Cl2Ru(p-cymene)](2)-catalyzed direct monoarylation of unactivated C(sp(3))-H bonds of 8-methyl quinolines with arylboronic acids to synthesize diarylmethane compounds is presented. The transformation shows a broad substrate scope with high chemoselectivity for the synthesis of 8-benzyl quinolines. In the preliminary mechanistic studies, control experiments, deuterium labeling experiments, and kinetic studies have been performed.
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