Statistical profiling of oral cancer and the prediction of outcome

Background The global burden of oral squamous cell carcinoma (OSCC) remains formidable. Identifying factors predictive of aggressive tumour behaviour, disease progression and reduced survival time may assist in early identification of high-risk patients and appropriately target combination cancer therapies. Methods A retrospective review of 467 OSCC patients treated over a 19-year period facilitated detailed clinico-pathological database analysis and determination of clinical outcome categories based upon time to progressive disease (loco-regional tumour recurrence and/or distant metastasis), overall death and OSCC-related death (death directly attributable to OSCC). Odds ratio (OR) and hazard ratio (HR) statistical measures were used to investigate relationships between patient demographics and clinico-pathological tumour features with clinical outcome. Results Older age at presentation (P = .002) and a history of previous non-head and neck cancer (P = .010) increased the risk of overall death. OR for progressive disease development (P = .008) and OSCC-related death (P = .019) was most significant for buccal tumours. HR confirmed advanced-stage disease increased the risk of progressive disease (P < .001), overall death (P < .001) and OSCC-related death (P < .001). Positive resection margins were associated with a higher risk of OSCC-related death (P = .023). Significantly lower risks of progressive disease development (P = .002) and OSCC-related death (P = .012) were seen in patients undergoing neck dissection, whilst combination chemoradiotherapy reduced HR for overall death (P < .001) and OSCC-related death (P = .011). Conclusion Statistical profiling of OSCC clinico-pathological data identifies significant influences on clinical outcome. This study adds evidence to the hypothesis that buccal SCC displays aggressive tumour behaviour and poor clinical outcome.

Automated summary

The study analyzed 467 OSCC patients over a 19-year period to determine factors influencing clinical outcomes. Older age and a history of previous non-head and neck cancer increased the risk of overall death, while buccal tumors significantly increased the risk of disease progression and OSCC-related death. Advanced-stage disease and positive resection margins were also associated with higher risks of negative outcomes. Patients undergoing neck dissection and combination chemoradiotherapy had lower risks of disease progression and related death.