期刊
JOURNAL OF NEUROSCIENCE
卷 40, 期 46, 页码 8799-8815出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3028-19.2020
关键词
anterior cingulate cortex; biophysical model; dendrite; electrical properties; NMDA spike; pyramidal neuron
资金
- Swiss National Science Foundation [159872, 156863, 180316]
- European Union [720270, 785907, 945539]
- European Research Council [682905]
- European Research Council (ERC) [682905] Funding Source: European Research Council (ERC)
Signal propagation in the dendrites of many neurons, including cortical pyramidal neurons in sensory cortex, is characterized by strong attenuation toward the soma. In contrast, using dual whole-cell recordings from the apical dendrite and soma of layer 5 (L5) pyramidal neurons in the anterior cingulate cortex (ACC) of adult male mice we found good coupling, particularly of slow subthreshold potentials like NMDA spikes or trains of EPSPs from dendrite to soma. Only the fastest EPSPs in the ACC were reduced to a similar degree as in primary somatosensory cortex, revealing differential low-pass filtering capabilities. Furthermore, L5 pyramidal neurons in the ACC did not exhibit dendritic Ca21 spikes as prominently found in the apical dendrite of S1 (somatosensory cortex) pyramidal neurons. Fitting the experimental data to a NEURON model revealed that the specific distribution of Ileak, Iir, Im, and Ih was sufficient to explain the electrotonic dendritic structure causing a leaky distal dendritic compartment with correspondingly low input resistance and a compact perisomatic region, resulting in a decoupling of distal tuft branches from each other while at the same time efficiently connecting them to the soma. Our results give a biophysically plausible explanation of how a class of prefrontal cortical pyramidal neurons achieve efficient integration of subthreshold distal synaptic inputs compared with the same cell type in sensory cortices.
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