期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 91, 期 12, 页码 1312-1315出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2020-323316
关键词
-
资金
- Medical Research Council [MR/L501529/1, MR/R024804/1]
- Economic and Social Research Council [ES/L008238/1]
- European Community [259 867, 633 413]
- Programme Grants for Applied Research
- National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London Maudsley Foundation Trust and King's College London
- Motor Neurone Disease Association
- ALS Association
- Patients Like Me
- Psychiatry Research Trust
- NIHR Bristol Biomedical Research Centre at University Hospitals Bristol National Health Service (NHS) Foundation Trust
- University of Bristol
- MRC [G0600974, MR/R024804/1] Funding Source: UKRI
Objective Smoking has been widely studied as a susceptibility factor for amyotrophic lateral sclerosis (ALS), but results are conflicting and at risk of confounding bias. We used the results of recently published large genome-wide association studies and Mendelian randomisation methods to reduce confounding to assess the relationship between smoking and ALS. Methods Two genome-wide association studies investigating lifetime smoking (n=463 003) and ever smoking (n=1 232 091) were identified and used to define instrumental variables for smoking. A genome-wide association study of ALS (20 806 cases; 59 804 controls) was used as the outcome for inverse variance weighted Mendelian randomisation, and four other Mendelian randomisation methods, to test whether smoking is causal for ALS. Analyses were bidirectional to assess reverse causality. Results There was no strong evidence for a causal or reverse causal relationship between smoking and ALS. The results of Mendelian randomisation using the inverse variance weighted method were: lifetime smoking OR 0.94 (95% CI 0.74 to 1.19), p value 0.59; ever smoking OR 1.10 (95% CI 1 to 1.23), p value 0.05. Conclusions Using multiple methods, large sample sizes and sensitivity analyses, we find no evidence with Mendelian randomisation techniques that smoking causes ALS. Other smoking phenotypes, such as current smoking, may be suitable for future Mendelian randomisation studies
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据