4.3 Review

Combined dystonias: clinical and genetic updates

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Summary: Deep brain stimulation (DBS) has shown promising clinical outcomes for myoclonus-dystonia (M-D), with significant improvements in myoclonus and dystonia symptoms. Older age at onset and shorter disease duration are associated with better myoclonus outcomes. Most adverse events are mild and transient, and pallidal stimulation may be favored due to fewer stimulation-induced events.

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