期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 10, 页码 3122-3130出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00719
关键词
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资金
- National Natural Science Foundation of China (NSFC) [31820103003, 31700042, 41676165]
- Chinese Academy of Sciences [QYZDJ-SSW-DQC004, XDA13020302]
- Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- Guangdong Province [GDME2018C005]
- Guangdong Provincial Special Fund for Marine Economic Development Project [[2020] 032]
Angucyclinces belong to the class of aromatic polyketides and display a wide variety of structure diversity and pharmaceutical significance. Herein we report the isolation, structure elucidation, and bioactivity evaluation of structure-diversified angucyclinone derivatives and anthracene from the South China Sea-derived Micromonospora echinospora SCSIO 04089, including a thioether, gephysulfuromycin (1), two new benzo[b]phenanthridines, homophenanthroviridone (2) and homophenanthridonamide (3), a new benzo[b]fluorene, homostealthin D (4), a new naphtho[2,3-b]benzofuran, nenesfuran (5), a new naphthoquinone, WS-5995 D (6) and a new anthracene, nenesophanol (7), together with three known compounds (8-10). Their structures were elucidated by extensive spectroscopic analyses. The structures of 1-3 and 5-8 were confirmed by X-ray crystallographic analyses. Gephysulfuromycin (1) featured a rare single S-bridged 3,12a-epithiotetraphene skeleton. Homophenanthroviridone (2) was found to be cytotoxic to SF-268, MCF-7, and HepG2 cell lines with IC50 values of 5.4 +/- 0.4, 6.8 +/- 0.3, and 1.4 +/- 0.1 mu M, respectively. Compound 2 was also active against Gram-positive bacteria with MIC (minimal inhibition concentration) values ranging 2-4 mu g mL(-1).
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