期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 10, 页码 2996-3003出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00535
关键词
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资金
- Natural Science Foundation of China [81670709]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- Major National Science and Technology Projects of the Ministry of Science and Technology [81991522]
- Fundamental Research Funds for the Central Universities [201941001]
- Pilot National Laboratory for Marine Science and Technology [2018SDKJ0401-2, LMDBKF201805]
- Taishan Scholar Youth Expert Program in Shandong Province [tsqn201812021]
- Natural Science Foundation of Fujian Province [2017J01145]
This project was focused on the discovery of novel compounds that promote endogenous beta-cell regeneration. Screening of extracts identified the fungus Stachybotrys chartarum as a promising candidate. After fermentation and extraction of S. chartarum, we isolated five new prenylated xanthones, namely, staprexanthones A-E (1-5), with staprexanthone A (1) being the first natural xanthone bearing a rare 4,5-dimethyl-1,3-dioxolane moiety. Compounds 1, 2, and 5 significantly increased beta-cell numbers in vivo in a zebrafish model. Further analysis revealed that 2 and 5 promoted beta-cell mass expansion by increasing proliferation of existing beta-cells though promotion of cell-cycle progression at the G1/S transition. These findings indicate that prenylated xanthones are potential new drug leads for antidiabetes therapy by stimulating beta-cell regeneration.
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