期刊
JOURNAL OF NATURAL MEDICINES
卷 75, 期 1, 页码 194-200出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-020-01449-y
关键词
Advanced glycation end products; Brown alga; Meroterpenoid; Sargassum macrocarpum
This study identified 11 meroterpenoids from brown alga Sargassum macrocarpum, with 3 new compounds showing inhibitory activity against AGEs. Among them, macrocarquinoid C exhibited the strongest activity, surpassing the positive control aminoguanidine.
The production and accumulation of advanced glycation end products (AGEs) have been implicated in diabetes and diabetic complication. This study was conducted as a search for an AGE inhibitor from brown alga,Sargassum macrocarpum.Separation and purification were performed using AGEs inhibitory activity as an index, yielding isolation of 11 meroterpenoids, of which 3 were new compounds: macrocarquinoids A (1), B (6), and C (9). Their structures were elucidated using NMR spectral analysis with 2D techniques. All tested compounds showed AGEs inhibitory activity. Particularly, macrocarquinoid C (9) possessed the strongest activity (IC50: 1.0 mM) of isolated compounds. This activity was stronger than that of aminoguanidine (positive control). [GRAPHICS] .
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