期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1227, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molstruc.2020.129353
关键词
Chitosan; Ferulic acid; Control release; Drug release kinetics
资金
- National Natural Science Foundation [20864001, 51861003]
- Key Project of the Guangdong Natural Science Foundation [04105934]
- Collaborative Innovation Center for Guangxi Sugar Industry, Guangxi
In this study, bovine serum albumin was loaded onto chitosan-ferulic acid conjugants as a model protein drug carrier. The conjugates exhibited high thermal stability and superior in vitro sustained release property, making them suitable for oral carrier in functional foods and drug delivery systems.
Herein, bovine serum albumin (BSA) as model protein drug was loaded on chitosan-ferulic acid (CS-FA) conjugants as protein drug carrier through the spray drying technique. The successful graft copolymerization of chitosan with ferulic acid was confirmed with FT-IR and XRD analyses. Additionally, the results of UV-Vis confirmed that the bovine serum albumin loading in the chitosan-ferulic acid-bovine serum albumin microcapsule was about 15.93%, respectively. The thermal properties of the conjugates were evaluated by means of thermogravimetric analysis and differential scanning calorimetry. The results revealed that the chitosan-ferulic acid conjugates exhibited low crystallinity but high thermal stability compared with that of chitosan. The pharmacokinetic study demonstrated that the chitosan-ferulic acid conjugates could provide a significantly higher swelling ratio and superior in vitro sustained release property. Furthermore, the results of drug release mechanism exhibited the corrode model was more accurately described the drug release behaviour involving a combination of drug diffusion and polymer relaxation. All these properties made chitosan-ferulic acid conjugates have potential to be developed as an oral carrier in functional foods and drug delivery systems. (C) 2020 Published by Elsevier B.V.
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