期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1215, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molstruc.2020.128291
关键词
Curcumin; Chalcone; Efflux pump; DFT; Spectroscopy; Docking
资金
- Portuguese Foundation for Science and Technology (FCT) [UIDB/00070/2020]
Curcumin, along with its derivatives, form a large class of natural and synthetic compounds with notable biological activity. However, their highly reactive beta-diketone moiety renders this type of compounds unstable at pH above 6.5. The substitution of this group for a mono-carbonyl solves this problem, while improving antibacterial and anti-inflammatory activities. A thiophene curcuminoid, (1E,4E)-1,5-Di(thiophen-2-yl)penta-1,4-dien-3-one (DB Thiophene), has been synthesised and its molecular and spectroscopic characterization is reported, as well as a complete vibrational assignment. An efflux pump inhibition assay determined that DB Thiophene exhibits a remarkable NorA and MepA efflux pump inhibition activity. Molecular docking studies were carried out in order to understand this inhibition mechanism. (C) 2020 Elsevier B.V. All rights reserved.
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