USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst

The Hantzsch three-component reaction is the best-known multicomponent reaction, affording dihydropyridines which have been employed therapeutically and also as visible-light photoredox catalysts. In this work we report the application of an ultra-stable (US) Y zeolite as a promising green catalyst in the synthesis of a series of 1,4-dihydropyridines under microwave irradiation. Using the optimized reaction conditions, 21 compounds were prepared in 64-96% isolated yields. The recovery and recycle of the USY zeolite are also reported as well as its fully characterization. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

This study utilized an ultra-stable Y zeolite as a catalyst to successfully synthesize a series of 1,4-dihydropyridines under microwave irradiation with high yields. The recovery and recycle of the USY zeolite were reported, along with its full characterization.