4.7 Article

Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Orthopedics

Oral Administration of a Chemically Modified Curcumin, TRB-N0224, Reduced Inflammatory Cytokines and Cartilage Erosion in a Rabbit ACL Transection Injury Model

Josephine R. Coury et al.

Summary: The study evaluated the effects of TRB-N0224 on a rabbit osteoarthritis model and found that it reduced cartilage pathologic changes, synovitis severity, and concentrations of key mediators like IL-1 beta and MMPs at different time points. This suggests the potential of TRB-N0224 to modulate MMP and cytokine levels, slowing the progression of OA.

CARTILAGE (2021)

Review Dentistry, Oral Surgery & Medicine

Periodontal therapeutics: Current host-modulation agents and future directions

Lorne M. Golub et al.

PERIODONTOLOGY 2000 (2020)

Review Multidisciplinary Sciences

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

Purva Singh et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Review Biochemistry & Molecular Biology

Redox and NF-κB signaling in osteoarthritis

Panagiotis Lepetsos et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Medicine, General & Internal

Osteoarthritis

David J. Hunter et al.

LANCET (2019)

Article Pharmacology & Pharmacy

Liquiritigenin inhibits IL-1β-induced inflammation and cartilage matrix degradation in rat chondrocytes

Chang Tu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Rheumatology

Critical role for arginase II in osteoarthritis pathogenesis

Wan-Su Choi et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Article Cell Biology

3′-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis

Jimin Jeon et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Pharmacology & Pharmacy

Curcumin protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis⁢ in vitro⁢

Ping Zhao et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Mithramycin A Alleviates Osteoarthritic Cartilage Destruction by Inhibiting HIF-2α Expression

Moon-Chang Choi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Osteoarthritis as a disease of the cartilage pericellular matrix

Farshid Guilak et al.

MATRIX BIOLOGY (2018)

Review Rheumatology

Novel Insights into the Pathogenesis of Osteoarthritis

M. Geyer et al.

CURRENT RHEUMATOLOGY REVIEWS (2018)

Review Orthopedics

ADAMTS and ADAM metalloproteinases in osteoarthritis-looking beyond the 'usual suspects'

C. -Y. Yang et al.

OSTEOARTHRITIS AND CARTILAGE (2017)

Article Multidisciplinary Sciences

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

Young-Ok Son et al.

NATURE COMMUNICATIONS (2017)

Review Medicine, Research & Experimental

Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Hamed Mirzaei et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Multidisciplinary Sciences

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Hiroshi Kobayashi et al.

NATURE COMMUNICATIONS (2016)

Review Chemistry, Medicinal

The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis

Kok-Yong Chin

DRUG DESIGN DEVELOPMENT AND THERAPY (2016)

Review Biochemistry & Molecular Biology

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

Hyun Sook Hwang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Biochemistry & Molecular Biology

Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes

Hiroaki Inoue et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Biochemistry & Molecular Biology

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

Giuseppe Musumeci et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Rheumatology

Role of HIF-1α and HIF-2α in osteoarthritis

Fang-Jie Zhang et al.

JOINT BONE SPINE (2015)

Article Biochemistry & Molecular Biology

Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives

Anthony C. Antonelli et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2014)

Article Rheumatology

Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

Brendan L. Thoms et al.

ARTHRITIS AND RHEUMATISM (2013)

Review Biochemistry & Molecular Biology

pKa, Zinc- and Serum Albumin-Binding of Curcumin and Two Novel Biologically- Active Chemically-Modified Curcumins

Yu Zhang et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

Makoto Hirata et al.

HUMAN MOLECULAR GENETICS (2012)

Review Orthopedics

HIF-2α as a possible therapeutic target of osteoarthritis

T. Saito et al.

OSTEOARTHRITIS AND CARTILAGE (2010)

Review Orthopedics

Biological actions of curcumin on articular chondrocytes

Y. Henrotin et al.

OSTEOARTHRITIS AND CARTILAGE (2010)