4.7 Article

Human Histone Interaction Networks: An Old Concept, New Trends

期刊

JOURNAL OF MOLECULAR BIOLOGY
卷 433, 期 6, 页码 -

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2020.10.018

关键词

histone; interaction; network; nucleosome; interactome

资金

  1. Intramural Research Program of the National Library of Medicine at the U.S. National Institutes of Health
  2. Department of Pathology and Molecular Medicine, Queen's University, Canada
  3. Ontario Institute of Cancer Research, Canada

向作者/读者索取更多资源

This study comprehensively mapped human histone interaction networks and found limited overlap between networks from different data sources. The analysis revealed scale-free behavior and high modularity of the human histone interactome, with a high number of residues involved in interactions. Additionally, two types of histone binding modes were detected.
To elucidate the properties of human histone interactions on the large scale, we perform a comprehensive mapping of human histone interaction networks by using data from structural, chemical cross-linking and various high-throughput studies. Histone interactomes derived from dierent data sources show limited overlap and complement each other. It inspires us to integrate these data into the combined histone global interaction network which includes 5308 proteins and 10,330 interactions. The analysis of topological properties of the human histone interactome reveals its scale free behavior and high modularity. Our study of histone binding interfaces uncovers a remarkably high number of residues involved in interactions between histones and non-histone proteins, 80-90% of residues in histones H3 and H4 have at least one binding partner. Two types of histone binding modes are detected: interfaces conserved in most histone variants and variant specific interfaces. Finally, dierent types of chromatin factors recognize histones in nucleosomes via distinct binding modes, and many of these interfaces utilize acidic patches among other sites. Interaction networks are available at https://github.com/Panchenko-Lab/Human-histone-interactome. (C) 2020 The Author(s). Published by Elsevier Ltd.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据