期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 433, 期 1, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2020.09.014
关键词
regulatory B cells; plasma cells; multiple sclerosis; experimental autoimmune encephalomyelitis
资金
- Canada CIHR Foundation [15992]
- MS Society of Canada [3194, 3490]
B cells play a critical role in the adaptive immune system by differentiating into plasmablasts and plasma cells to produce antibodies. Plasmablasts/plasma cells can survive for years in the bone marrow and intestine, producing cytokines and acting as regulatory cells.
B cells are a critical arm of the adaptive immune system. After encounter with antigen, B cells are activated and differentiate into plasmablasts (PBs) and plasma cells (PCs). Although their frequency is low, PB/PCs can be found in all lymphoid organs including peripheral lymph nodes and spleen. Upon immunization, depending on the location of where B cells encounter their antigen, PB/PCs subsequently home to and accumuate in the bone marrow and the intestine where they can survive as long-lived plasma cells for years, continually producing antibody. Recent evidence has shown that, in addition to producing antibodies, PB/PCs can also produce cytokines such as IL-17, IL-10, and IL-35. In addition, PB/PCs that produce IL-10 have been shown to play a regulatory role during experimental autoimmune encephalomyelitis, an animal model of neuroinflammation. The purpose of this review is to describe the phenotype and function of regulatory PB/PCs in the context of experimental autoimmune encephalomyelitis and in patients with multiple sclerosis. (C) 2020 Elsevier Ltd. All rights reserved.
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