期刊
JOURNAL OF MEDICAL VIROLOGY
卷 93, 期 5, 页码 2645-2653出版社
WILEY
DOI: 10.1002/jmv.26595
关键词
generalized infection; immune response; immune system; immunopathology; innate immunity; pathogenesis
类别
资金
- [R01AI120622]
- [R01 DK117004]
- [R01 AI127463]
- [2P30 DK48522]
COVID-19, caused by SARS-CoV-2, has led to a global pandemic with significant impacts on health, society, and economy. The disease presents with diverse clinical manifestations involving multiple organ systems, potentially influenced by viral tropism and abnormal host immune response. Further studies are needed to better understand the pathophysiological mechanisms and identify therapeutic targets.
Coronavirus disease 2019, the infectious disease caused by severe acute respiratory syndrome coronavirus-2, has resulted in a global pandemic with unprecedented health, societal, and economic impact. The disease often manifests with flu-like symptoms and is dominated by pulmonary complications, but widely diverse clinical manifestations involving multiple organ systems can result. We posit that viral tropism and the aberrant host immune response mediate the protean findings and severity in this disease. In general, extrapulmonary manifestations are a harbinger of or contemporaneously associate with disease progression, but in the case of some extrapulmonary findings (gastrointestinal and dermatologic), may track with milder disease. The precise underlying pathophysiological mechanisms remain incompletely elucidated, and additional immune phenotyping studies are warranted to reveal early correlates of disease outcomes and novel therapeutic targets.
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