Human parvovirus 4: An emerging etiological agent in cases presenting with influenza like illness

This study was planned to study the association of parvovirus 4 (PARV4) with Influenza-like illness (ILI). A total of 1111 patients with a clinical diagnosis of ILI and 220 healthy controls were tested for Influenza A/HINI/and H3N2, Influenza B, and PARV4. Further sequencing was done to analyze the genotype distribution of parvovirus 4. Influenza A/HINI, A/H3N2, and B were detected in 334 (30.06%), 9 (0.81%), and 10 (0.9%) cases respectively. PARV4 was detected in 135 (12.15%) cases and one healthy control. Parvovirus 4 was significantly higher in cases as compared to controls (relative risk, 30.77%; p < .0006). Sequencing of 20 isolates suggests the dominance of genotype 2 in our region.

Automated summary

This study found a significant association of parvovirus 4 (PARV4) with Influenza-like illness (ILI), with a higher detection rate of PARV4 in cases compared to controls, and genotype 2 dominance in the region based on sequencing analysis of 20 isolates.