期刊
JOURNAL OF MATERIALS SCIENCE
卷 56, 期 1, 页码 691-705出版社
SPRINGER
DOI: 10.1007/s10853-020-05190-5
关键词
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资金
- China Scholarship Council (CSC)
- University Wurzburg
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [326998133-TRR 225]
- Deutsche Forschungsgemeinschaft within the DFG State Major Instrumentation Programme [INST 105022/58-1 FUGG]
This study presents a hybrid system of nanoclay and thermoresponsive block copolymer as a novel biomaterial ink, demonstrating improved mechanical properties and enhanced printing quality for extrusion-based bioprinting.
As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (PMeOx-b-PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability. The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (similar to 1 s) and structure recovery (similar to 10 s), is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay. Graphic abstract
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