期刊
JOURNAL OF INFECTIOUS DISEASES
卷 223, 期 5, 页码 796-801出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa656
关键词
SARS-CoV-2; ELISA; CLIA; ECLIA; CMIA; neutralization test; spike; nucleocapsid
资金
- German Federal Ministry of Health (Bundesministerium fur Gesundheit)
This study provides a comparative validation of 4 anti-SARS-CoV-2 platforms, with Euroimmun and Roche platforms showing the highest sensitivities for screening individuals at increased risk of SARS-CoV-2 infections.
Highly sensitive and specific platforms for the detection of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are becoming increasingly important for evaluating potential SARS-CoV-2 convalescent plasma donors, studying the spread of SARS-CoV-2 infections, and identifying individuals with seroconversion. This study provides a comparative validation of 4 anti-SARS-CoV-2 platforms. A unique feature of the study is the use of a representative cohort of convalescent patients with coronavirus disease 2019 and a mild to moderate disease course. All platforms showed significant correlations with a SARS-CoV-2 plaque reduction neutralization test, with highest sensitivities for the Euroimmun and the Roche platforms, suggesting their preferential use for screening persons at increased risk of SARS-CoV-2 infections.
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