期刊
JOURNAL OF IMMUNOLOGY
卷 205, 期 9, 页码 2327-2341出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1901430
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资金
- National Science Foundation Graduate Research Fellowship Program
- National Cancer Institute, National Institutes of Health [R21 CA246550, R37 CA230786]
- University Cancer Research Fund, The University of North Carolina at the Chapel Hill Lineberger Comprehensive Cancer Center
- North Carolina Translational and Clinical Sciences Institute, The University of North Carolina at Chapel Hill (NC Translational and Clinical Sciences Institute) [TTSA023P1]
Focused ultrasound (FUS) has recently emerged as a modulator of the tumor microenvironment, paving the way for FUS to become a safe yet formidable cancer treatment option. Several mechanisms have been proposed for the role of FUS in facilitating immune responses and overcoming drug delivery barriers. However, with the wide variety of FUS parameters used in diverse tumor types, it is challenging to pinpoint FUS specifications that may elicit the desired antitumor response. To clarify FUS bioeffects, we summarize four mechanisms of action, including thermal ablation, hyperthermia/thermal stress, mechanical perturbation, and histotripsy, each inducing unique vascular and immunological effects. Notable tumor responses to FUS include enhanced vascular permeability, increased T cell infiltration, and tumor growth suppression. In this review, we have categorized and reviewed recent methods of using therapeutic ultrasound to elicit an antitumor immune response with examples that reveal specific solutions and challenges in this new research area.
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