期刊
JOURNAL OF HUMAN GENETICS
卷 66, 期 3, 页码 261-271出版社
SPRINGERNATURE
DOI: 10.1038/s10038-020-00827-4
关键词
-
资金
- National Natural Science Foundation of China [31930053, 31421003, 31671168]
The study explored the genetic basis of two subtypes of the Ebbinghaus illusion in humans, finding moderate heritability for EI overestimation but not for EI underestimation. Through quantitative genomic analyses, a number of SNPs and genes associated with EI overestimation were identified, providing consistent evidence for a substantial genetic basis of the Ebbinghaus illusion.
The Ebbinghaus illusion (EI) is an optical illusion of relative size perception that reflects the contextual integration ability in the visual modality. The current study investigated the genetic basis of two subtypes of EI, EI overestimation, and EI underestimation in humans, using quantitative genomic analyses. A total of 2825 Chinese adults were tested on their magnitudes of EI overestimation and underestimation using the method of adjustment, a standard psychophysical protocol. Heritability estimation based on common single nucleotide polymorphisms (SNPs) revealed a moderate heritability (34.3%) of EI overestimation but a nonsignificant heritability of EI underestimation. A meta-analysis of two phases (phase 1:n = 1986, phase 2:n = 839) of genome-wide association study (GWAS) discovered 1969 and 58 SNPs reaching genome-wide significance for EI overestimation and EI underestimation, respectively. Among these SNPs, 55 linkage-disequilibrium-independent SNPs were associated with EI overestimation in phase 1 with genome-wide significance and their associations could be confirmed in phase 2 cohort. Gene-based analyses found seven genes to be associated with EI overestimation at the genome-wide level, two from meta-analysis, and five from classical two-stage analysis. Overall, this study provided consistent evidence for a substantial genetic basis of the Ebbinghaus illusion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据