Synthesis, antimicrobial, and mitotic toxicity evaluation of new 6-substituted 2-(benzo[4,5]imidazo[1,2-c]quinazolin-5(6H)-yl)acetic acids

A series of novel 6-substituted 2-(benzo[4,5]imidazo[1,2-c]quinazolin-5(6H)-yl)acetic acids were synthesized and characterized by(1)H,C-13,F-19 NMR,H-1-H-1-COSY,H-1-C-13-HSQC, NOESY, LC-MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the Allium test procedure. The 2-(6-(pentafluorophenyl)benzo[4,5]imidazo[1,2-c]quinazolin-5(6H)-yl)acetic acid inhibited mitotic spindle formation, which resulted in significant cytotoxic effect for meristematic cells ofAllium cepal. roots. In a preliminary antimicrobial evaluation, onlyStreptococcus pyogenesandCandida albicanswere slightly susceptible to some of the synthesized compounds.

Automated summary

A series of novel compounds were synthesized and characterized, showing significant cytotoxicity for meristematic cells and slight susceptibility to some microbial strains.