Agreement between wedged hepatic venous pressure and portal pressure in non-alcoholic steatohepatitis-related cirrhosis

Background & Aims: Wedge hepatic vein pressure (WHVP) accurately estimates portal pressure (PP) in alcohol-or viral hepatitis-related cirrhosis. Whether this also holds true in cirrhosis caused by non-alcoholic steatohepatitis (NASH) is unknown. We aimed to evaluate the agreement between WHVP and PP in patients with NASH cirrhosis in comparison to patients with alcohol-or HCV-related cirrhosis. Methods: All consecutive patients with NASH cirrhosis treated with a transjugular intrahepatic portosystemic shunt (TIPS) in 3 European centres were included (NASH group; n = 40) and matched with 2 controls (1 with alcohol-related and 1 with HCV-related cirrhosis) treated with TIPS contemporaneously (control group; n = 80). Agreement was assessed by Pearson's correlation (R), intra-class correlation coefficient (ICC), and Bland-Altman method. Disagreement between WHVP and PP occurred when both pressures differed by >10% of PP value. A binary logistic regression analysis was performed to identify factors associated with this disagreement. Results: Correlation between WHVP and PP was excellent in the control group (R 0.92; p<0.001; ICC 0.96; p<0.001) and moderate in the NASH group (R 0.61; p<0.001; ICC 0.74; p<0.001). Disagreement between WHVP and PP was more frequent in the NASH group (37.5% vs. 14%; p = 0.003) and was mainly because of PP underestimation. In uni- and multivariate analyses, only NASH aetiology was associated with disagreement between WHVP and PP (odds ratio 4.03; 95% CI 1.60-10.15; p = 0.003). Conclusions: In patients with decompensated NASH cirrhosis, WHVP does not estimate PP as accurately as in patients with alcohol-or HCV-related cirrhosis, mainly because of PP underestimation. Further studies aimed to assess this agreement in patients with compensated NASH cirrhosis are needed. Lay summary: Portal pressure is usually assessed by measuring wedge hepatic vein pressure because of solid evidence demonstrating their excellent agreement in alcohol-and viral hepatitis related cirrhosis. Our results show that in patients with decompensated cirrhosis caused by non-alcoholic steatohepatitis, wedge hepatic vein pressure estimates portal pressure with less accuracy than in patients with other aetiologies of cirrhosis, mainly because of portal pressure underestimation. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Automated summary

In patients with decompensated cirrhosis caused by non-alcoholic steatohepatitis, wedge hepatic vein pressure does not estimate portal pressure as accurately as in patients with alcohol-or HCV-related cirrhosis, mainly because of portal pressure underestimation.