Nanomolar level detection of non-steroidal antiandrogen drug flutamide based on ZnMn2O4 nanoparticles decorated porous reduced graphene oxide nanocomposite electrode

Flutamide is a non-steroidal antiandrogen drug and widely used in the treatment of prostatic carcinoma. Nevertheless, the excessive intake and improper disposal could affect the living organisms. In this work, we have synthesized a new nanocomposite based on ZnMn2O4 nanoparticles and porous reduced graphene oxide nanosheets (ZnMn2O4-PGO) for the electrocatalytic detection of flutamide (FLU) drug. The crystallinity and morphological properties of ZnMn2O4-PGO composite examined by different characterization techniques such as X-ray diffraction, Raman spectroscopy and so on. The fabricated ZnMn2O4-PGO nanocomposite modified electrode exhibited superior electrocatalytic performance to FLU drug in an optimized pH electrolyte. Fascinatingly, the electrode received a wide linear range (0.05-3.5 mu M) with limit of detection of 8 nM. Besides, the developed ZnMn2O4-PGO nanocomposite electrode showed good sensitivity 1.05 mu A mu M-1 cm(-2) and excellent selectivity for FLU detection in presence of various interfering species. A developed disposable electrode was scrutinized to determine FLU level in human urine samples by spiking method and the results achieved good recoveries in real sample analysis.

Automated summary

A new nanocomposite ZnMn2O4-PGO was synthesized for the electrocatalytic detection of flutamide drug, demonstrating superior performance in sensitivity and selectivity. The electrode showed a wide linear range and excellent detection capability in human urine samples, achieving good recoveries in real sample analysis.