4.6 Article

The effects of different postures and provocative swallow materials on the normative Chicago 3.0 metrics in a healthy Asian population

期刊

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 36, 期 5, 页码 1244-1252

出版社

WILEY
DOI: 10.1111/jgh.15284

关键词

Asian; body position; Chicago classification; high-resolution esophageal manometry; Malay; solid; viscous

资金

  1. Universiti Sains Malaysia [304/PPSP/61313083]
  2. Hospital Canselor Tuaku Muhriz [UKM FPR.4/244/FF-2015-306]
  3. Malaysian Society of Gastroenterology Hepatology

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Variations in the Chicago 3.0 normative metrics exist in a healthy Asian population with different postures and provocative swallow materials. Upright posture may lead to more motility disorders.
Background and Aim Variations in the Chicago 3.0 normative metrics may exist with different postures and with different provocative swallow materials in a healthy Asian population. Method Eligible healthy Malay volunteers were invited to undergo the high-resolution esophageal manometry (inSIGHT Ultima, Diversatek Healthcare, Milwaukee, WI, USA). In recumbent and standing positions, test swallows were performed using liquid, viscous, and solid materials. Metrics including integrated relaxation pressure 4 s (IRP-4 s, mmHg), distal contractile integral (DCI, mmHg s cm), distal latency (DL, s), and peristaltic break (PB, cm) were reported in median and 95th percentile. Results Fifty of 57 screened participants were recruited, and 586 saline, 265 viscous, and 261 solid swallows were analyzed. Per-patient wise, in the recumbent position, 95th percentile for IRP-4 s, DCI, DL, and PB were 16.5 mmHg, 2431 mmHg s cm, 8.5 s, and 7.2 cm, respectively. We observed that with each posture, the use of viscous swallows led to changes in DL, but the use of solid swallows led to more changes in the metrics including DCI and length of PB. Compared with a recumbent posture, anupright posture led to lower IRP-4 s and DCI values. Both per-patient analysis and per-swallow analyses yielded almost similar results when comparing the different postures and types of swallows. No major motility disorders were observed in this cohort of asymptomatic population. However, more motility disorders were reported in the upright position. Conclusions Variations in metrics can be observed in different postures and with different provocative swallow materials in a healthy population. The normative Chicago 3.0 metrics are also determined for the Malay population.

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