期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 218, 期 1, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20200649
关键词
-
资金
- National Institutes of Health [AI145828, HD097400]
- Magee-Womens Research Institute Clinical Trainee Research Award [4032]
- Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center Health System
- [P30CA047904]
The study reveals that the human placenta uses the inflammasome mechanism to regulate systemic and local immunity during pregnancy to defend against L. monocytogenes infection.
The human placenta is a dynamic organ that modulates physiological adaptations to pregnancy. To define the immunological signature of the human placenta, we performed unbiased profiling of secreted immune factors from human chorionic villi isolated from placentas at mid and late stages of pregnancy. We show that placental trophoblasts constitutively secrete the inflammasome-associated cytokines IL-1 beta and IL-18, which is blocked by NLRP3 inflammasome inhibitors and occurs without detectable gasdermin D cleavage. We further show that placenta-derived IL-1 beta primes monocytes for inflammasome induction to protect against Listeria monocytogenes infection. Last, we show that the human placenta responds to L. monocytogenes infection through additional inflammasome activation and that inhibition of this pathway sensitizes villi to infection. Our results thus identify the inflammasome as an important mechanism by which the human placenta regulates systemic and local immunity during pregnancy to defend against L. monocytogenes infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据