期刊
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
卷 39, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13046-020-01706-8
关键词
m6A modification; RNA; Central nervous system; Glioma; Glioblastoma; GBM; Tumourigenesis
类别
资金
- Natural Science Foundation of Hebei Province in 2020 [H2020201050]
- High-level Talents Scientific Research Launched Project of Hebei University [521000981301]
- Science and Technology Capacity Improvement Projects of Hebei University of Chinese Medicine [KTZ2019019]
- Outstanding Student Scientific Research Ability Improvement Projects of Hebei University of Chinese Medicine [YXZ2019002]
- Graduate Innovative Ability Training Projects of Hebei University of Chinese Medicine [XCXZZBS2020002]
- Hebei University [hbu2020bs003]
- Foundation Project of Affiliated Hospital of Hebei University [2019Q009]
- [360017]
The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. As the most common malignant tumour of the central nervous system, gliomas (especially glioblastoma) have a very poor prognosis, and treatment efficacy is not ideal even with the application of high-intensity treatment measures of surgery combined with chemoradiotherapy. Exploring the origin and development mechanisms of tumour cells from the perspective of tumour biogenesis has always been a hotspot in the field of glioma research. Emerging evidence suggests that m6A modification can play a key role in gliomas through a variety of mechanisms, providing more possibilities for early diagnosis and targeted therapy of gliomas. The aim of the present review is to focus on the research progress regarding the association between m6A modification and gliomas. And to provide a theoretical basis according to the currently available literature for further exploring this association. This review may provide new insights for the molecular mechanism, early diagnosis, histologic grading, targeted therapy and prognostic evaluation of gliomas.
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