A sensitive electrochemical sensor based on aluminium doped copper selenide nanoparticles-modified screen printed carbon electrode for determination of L-tyrosine in pharmaceutical samples

A simple method for the quantitative and determination of L-tyrosine was proposed in this work. Aluminium doped copper selenide nanoparticles (Al-CuSe-NPs), were used to modify screen printed carbon electrode (SPCE) to study the electrochemical behavior of L-tyrosine using voltammetric techniques such as cyclic voltammetry (CV) and linear sweep voltammetry (LSV). Al-CuSe-NPs were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The electrochemical results demonstrated that the Al-CuSe-NPs/SPCE exhibited high electro-catalytic activity and good analytical performance towards the detection of L-tyrosine. The linear range of L-tyrosine was 0.15-10 mu M with correlation coefficient of 0.9974. The detection limit of the L-tyrosine was 0.04 mu M. In addition, the Al-CuSe-NPs/SPCE exhibited good selectivity, high sensitivity and good reproducibility towards the determination of L-tyrosine, making it suitable sensor for the determination of L-tyrosine in pharmaceutical samples.