Improved oral delivery of quercetin with hyaluronic acid containing niosomes as a promising formulation

Quercetin, a substance from nature has various biological effects; while, some challenges like low solubility in water and absorption, and high first-pass metabolism hindered its clinical efficiencies. So, various strategies using novel nanocarriers have been designed to overcome these obstacles. This study aimed to fabricate the polymeric niosomes by incorporating hyaluronic acid to deliver quercetin. After preparation, quercetin entrapped niosomes were investigated in terms of size, zeta potential, quercetin entrapment, CTAB turbidimetric assay, AFM, TEM, differential scanning Calorimetry, X-Ray diffraction, DPPH antioxidant determination, andin vivoanti-inflammatory analysis. The analysis of the results exhibited that size of niosomes containing quercetin and hyaluronic acid was 231.07 +/- 8.39 nm with a zeta potential of -34.00 +/- 0.95 mV. Moreover, quercetin entrapment efficiency and loading were 94.67 +/- 1.62% and 1.65 +/- 0.37%, respectively. TEM and AFM showed that polymeric niosomes were spheres. The release data presented that the Higuchi model was the best-fitted model. DPPH antioxidant determination displayed that 80 mu l of polymeric niosomes with 7.46 x 10(-8 )mol of quercetin had a remarkable antioxidant potency. According to thein vivooedema evaluation, the potency of polymeric formulations was superior to the simple suspension of quercetin to control inflammation in rats by oral administration.

Automated summary

This study aimed to fabricate polymeric niosomes by incorporating hyaluronic acid to deliver quercetin, and a series of analyses revealed that these nanocarriers have good size, loading capacity, and antioxidant properties, showing superior potency in controlling inflammation in rats compared to a simple quercetin suspension through oral administration.